Endocrine Abstracts

cAMP is implicated in the regulation of a variety of cell functions that are related to activation of multiple intracellular pathways. In addition to the control of differentiated functions, such as hormone secretion, cAMP inhibits or stimulates cell proliferation depending on the cell type. In particular, consistent with the frequent expression of somatic mutations constitutively activating Gs alpha subunit (gsp oncogene) in GH-secreting adenomas, the activation of cAMP depen...

Anna Spada is currently Full Professor at the School of Medice, University of Milan. Her main research interests are on signal transduction in pituitary cells, pathogenesis of pituitary tumors, genotype/phenotype relationships in acromegalic patients with gsp mutations, tissue specific GNAS1 gene imprinting, molecular mechanisms of resistance to hormone action, activating and inactivating mutations of GNAS1 in endocrine disorders, polymorphic variants of somatostatin receptor ...

Lipodystrophy is a group of rare disorders characterized by complete or partial loss of adipose tissue. Lipodystrophy can be inherited or acquired and may present in childhood or in adults. Metabolic sequelae of lipodystrophy include severe insulin resistance (SIR), type 2 diabetes, hypertriglyceridaemia, hepatic steatosis and hyperandrogenism. Research in our centre has produced a database of several hundred patients with lipodystrophy and/or SIR and has contributed to identi...

Unintended pregnancy is common. Most European governments are concerned by abortion rates which, if not rising, seem stubbornly difficult to reduce. Moreover by no means all unintended pregnancies are aborted: in the UK, almost one third of pregnancies which end in childbirth are unplanned or mistimed. While no method of contraception is 100% effective, few induced abortions are the result of true method failures; most are due to unprotected sex or incorrect/ inconsistent use ...

Laser Doppler fluorometry (LDF) is not an invasive method for diagnosing microcirculation in patients with diabetes mellitus, but the method needs to be improved. Evaluation of the LDF method in patients with diabetic neuropathy (DN) before and after the appointment of vitamin D (VD). Included patients with DM and VD deficiency, DM duration more then 5 years, HbA1c up to 9.0%, non-smokers, signed IC. LAKK-M was used. The value of perfusion was measured-M, σ- average modul...

Approximately 2.6 billion people worldwide (38% of the planet’s population) are already overweight or obese. In 12 years, according to analysts’ forecasts, every second person on the planet will have an excess of fat. Unfortunately, adhering to diets only contributes to weight gain. Under calorie restriction, physiological adaptation mechanisms are activated in the body, which increase hunger and reduce basal metabolism. In such conditions, weight loss is possible on...

Background: The glucagon stimulation test (GST) involves administering an injection of glucagon and monitoring respondent levels of cortisol, growth hormone and glucose in the blood. The levels recorded are compared to current standard recommendations in order to offer a suggestion into growth hormone or cortisol deficiency. Many children who underwent the GST to investigate growth hormone deficiency (GHD) or prior to transfer to adult endocrine clinic failed to reach the adeq...

Introduction: Obesity is a chronic disease which has become a global epidemic. Approximately 7% of deaths per year is associated with obesity, especially because of its complications such as cardiovascular diseases, type 2 diabetes or cancer. Lifestyle interventions are the first line of management but additional pharmacotherapy or bariatric surgery should be considered in more severe cases.Case report: A 40-year-old woman was referred to Endocrinology O...

Hypogonadotropic hypogonadism as a part of hypopituitarism can be a cause of persistent amenorrhea and hypoestrogenemia in women of reproductive age as it is observed in postmenopause. We know that premature and early menopause leads to accelerated aging with such markers as decreased quality of life, phyco-emotional deprivation, dyslipidemia, bone mineral density and others. We hypothesized that untreated hypogonadism in young women with hypopituitarism could cause premature ...

Childhood cancer survivors are a growing population. Lifelong endocrine follow up is essential for brain tumour and bone marrow transplant survivors who received radiotherapy. Patients attending the ‘late effects’ clinic have investigations coordinated with an annual appointment including endocrine bloods, urine protein:creatinine ratio, blood pressure and weight. The Covid-19 pandemic necessitated appointments to be telephone. Patients were asked to arrange their an...